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The monoamine hypothesis of depression has been the main pathophysiology and drug therapy target of depression over the past few decades, but the current monoamine theory has serious limitations ( The relationship of multiple ACs in vivo and psychiatric disorders such as depression has yet to be further investigated
However, you may find you need melatonin less as your sleep quality naturally improves with treatment
Without insurance coverage, Ozempic can cost $1,300 or more, but there are several ways to reduce drug costs
Either diet & exercise or medication
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