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Oxidative stress-induced formation of methionine sulfoxide can spontaneously react with hydroxyl radical and generates methyl radical that non-specifically and non-enzymatically methylate DNA cytosine and may affect the epigenome 38

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Exceeding recommended doses (typically above 1,000 mg/day) increases the likelihood of digestive side effects such as bloating, cramping, and loose stools

Key trials and reviews include a recent review, a randomized trial, and an MDPI analysis