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Gastric lavage or induced emesis are not usually attempted due to low efficacy beyond the first hour and high aspiration risk
By stimulating these two receptors, Tirzepatide not only increases insulin secretion in response to high blood sugar but also curbs appetite and slows down gastric emptying, leading to prolonged feelings of fullness
The more clinically relevant question is whether controlled glucagon receptor activation, when paired with GLP-1 and/or GIP receptor agonism, can shift glucagons metabolic impact from primarily hyperglycemic toward thermogenic, lipolytic, and hepatometabolic benefit
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