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In a case-control study involving 105 patients [43] , heterozygous MC4R pathogenic/likely pathogenic (P/LP) variant carriers exhibited similar maximum total body weight loss percentage (%TBWLmax) to non-carriers (28.3% 8.5% vs

Muscle preservation during GLP-1 or medical weight-loss treatment depends heavily on protein intake, resistance training, adequate nutrition, dose management, sleep, hormones, and medical monitoring

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One of the primary obstacles is the cost, as TZP is relatively expensive and may not be accessible to all patients, particularly in healthcare systems with limited coverage for newer medications