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Semaglutide Medication class: Semaglutide is a GLP-1 receptor agonist Tirzepatide acts on both GLP-1 and GIP receptors Use: Both are injectable prescription medications used alongside diet and exercise to support blood sugar regulation and weight management in adults Dosing: Both medications are typically administered as a once-weekly injection, based on individual treatment plans Effect profile: Both work by influencing appetite regulation and glucose metabolism Individual response and tolerance may vary Side effects: Common side effects may include nausea, vomiting, diarrhea, constipation, or abdominal discomfort Side effects and tolerability differ between individuals Treatment selection: Choice of medication is based on medical history, clinical evaluation, and provider recommendation Formulation: At NP ON DEMAND, these medications may be provided as compounded formulations, which may include bacteriostatic water (BAC), vitamin B12, or glycine, depending on individual treatment plans Who Should Not Use GLP-1 Medications

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mBio 8 , e00859-17 (2017)