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Dosing and Administration Typical Dose : 1.25 mg to 2 mg (0.250.4 mL) per dose Administration : Intranasal spray in one or both nostrils , as directed Timing : Use 1530 minutes before anticipated sexual activity Frequency : No more than 1 dose per 24-hour period

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However, clinical research increasingly recognized that patients with metabolic diseases frequently experience clusters of systemic complications, including heart failure (HF), chronic kidney disease (CKD), and fatty liver disease, that single-target drugs historically failed to address comprehensively