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This unorganized drug matrix allows loading of more drugs in the core and enhances the stability issues observed earlier for on storage of SLN on long term basis due to drug expulsion and crystallization [50]
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And, when the V max values are set to 10% of their normal values, the number of functional hepatocytes decreases to 10% of normal after 40 hours (the red curve), well below the grey bar marking 30% remaining hepatocytes, which is thought to be the threshold for liver failure[10]
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