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Intima-media thickness (IMT) measured at a common carotid artery level is widely used as an effective, non-invasive surrogate measure of atherosclerosis [89]

This means that the clinical effectiveness of GSHand that of its precursors like NACis dependent not only on its capability to act as an antioxidant, but also the degree to which their pharmacodynamic properties are in line with the dysfunction in cellular signaling, redox imbalance, and immune response generated by specific disease states (Fraternale et al., 2021)