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Rheum rhabarbarum is a perennial herb that belongs to the buckwheat family
The performance and financial cost of extended absence create motivation to explore off-label options despite regulatory and safety uncertainties
Tendon and ligament repair, gastrointestinal mucosal healing, soft tissue recovery, and neuroprotective signaling are all supported by reproducible rodent and in vitro work, while the human evidence remains limited to one unpublished Phase 2 IBD trial and a small number of preliminary studies
A planned Phase I safety trial of 42 healthy volunteers receiving oral BPC-157 was conducted in 2015, but results were never formally published following cancellation of planned submission in 2016
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