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A 2025 meta-analysis confirmed that GLP-1 RAs significantly reduced BMI z-score, waist circumference, and body weight in children and adolescents with obesity [129]
Since glutaminase 1 (GLS1), a key mitochondrial enzyme that catalyzes the deamidation of glutamine, was first discovered in the kidney in 1958 9 , many enzymes involved in glutamine metabolism have been reported 4
41 During myocardial ischemia-reperfusion, mitochondrial oxidative phosphorylation is disrupted, reducing ATP production, while elevated calcium ion concentrations adversely affect mitochondrial function
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