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In the GI tract, they are present on enteroendocrine cells that produce a range of gut hormones (including GLP-1, cholecystokinase [CCK], and peptide YY [PYY]) when the TAS2R is activated by a bitter substance
Single and dual agonists The fundamental difference between these two molecules is that semaglutide is a GLP-1 agonist, i.e., it has a strong structural similarity (95%) with this hormone and specifically activates its receptor, while tirzepatide is a dual agonist, i.e., it has a hybrid structure that allows it to activate both GLP-1 and GIP receptors (Figure 2)
After seven weeks, the group that received the diet without supplemental L-carnitine lost 1.8% body weight compared to 6.4% body weight loss from the group that was fed the L-carnitine supplemented diet
