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In the future, we will develop small molecule inhibitors or activators for specific transporters such as SLC25A39 and xCT, and use gene editing tools (such as CRISPR/Cas9) to precisely edit related genes to achieve precise regulation of GSH metabolism, providing more targeted means for disease treatment
Nature 411, 595599
Cysteine preservation confers resistance to glutathione-depleted cells against ferroptosis via CDGSH iron Sulphur domain-containing proteins (CISDs)
Mechanism clarity : Oveporexton has a defined single-target mechanism (OX2R)
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