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A solution of DIBOC (36.08 gm) in toluene (260 ml) was slowly added to the reaction mixture at 75-80C and stirred for 9 hr at the same temperature
Pathogenic variants in the MTHFR gene results in a form of homocysteinemia that is often referred to as hyperhomocysteinemia
Initial blood work is recommended to confirm whether a patient is genuinely deficient in B12 and needs supplementation, or whether another underlying issue may be affecting energy, weight, or metabolic function
Tamamoullari N, Sili Y, Iaasiolu S, Atalay A
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