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Patients with low B12 tend to catch more colds and recover more slowly
As a result, GLP- 1's primary effects include decreasing body weight, protecting against cardiovascular disease, and lowering fasting and postprandial blood glucose levelsall of which are therapeutic targets in T2DM
What was studied: Cardiovascular death and worsening of heart failure over a median follow-up of roughly two years Outcome: Tirzepatide reduced the combined risk of cardiovascular death and worsening heart failure events by approximately 38%, driven largely by a 46% reduction in worsening heart failure events requiring hospitalization or urgent care
There is a theoretical case for using both in certain patients, targeting different physiological mechanisms simultaneously, though this approach is under evaluation and not yet standard of care
