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Although DCE MRI can detect subtle changes in BBB permeability in well-controlled cohorts, differences in scanning equipment, parameters, and data processing between data collection sites can dilute these relatively small changes associated with AD and aging, which are typically one order of magnitude lower than the more robust changes of other disorders like ischemic stroke (Heye et al., 2014
Reconstitute DSIP at Home: Inject 1 mL bacteriostatic water slowly into the 10 mg DSIP vial along the side
Passive transport occurs through transcellular diffusion, while the active transcellular transport pathway includes receptor-mediated endocytosis, active efflux transport, and adsorption-mediated endocytosis [61]
The two can be combined, as they work through different mechanisms
