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Examples include: Insulin regulates blood sugar in diabetes GLP-1 medications (semaglutide, tirzepatide) used for diabetes and weight management Calcitonin used in bone metabolism disorders These medications underwent years of clinical trials and regulatory review before becoming approved treatments

Similarly, ICV injection of Ex-4 increased c-fos expression in alpha-melanocyte stimulating hormone (alpha-MSH)-immunoreactive neurons in the ARC of mice (Dalvi et al., 2012)