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Those with serious diseases related to kidneys and the heart or those taking immunosuppressive medications need permission from their physician
Four months after cessation of LC supplementation, plasma TMAO reached a pre-supplementation concentration, which was stable for the following 8 months [60]
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Due to its plasma half-life of approximately 3.8-6.9 hours, a twice-daily (BID) dosing schedule may be used to provide more consistent and sustained inhibition of NNMT throughout the day, potentially maximizing its metabolic effects
