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Therefore, the inhibition of SGLT2 may reduce the activity of URAT1 by enhancing luminal glucose transmission or lowering insulin levels, or SGLT2 and URAT1 may functionally interact in the proximal tubule, thereby inhibiting SGLT2 to partially suppress URAT1 (Novikov et al., 2019

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A new study suggests that people taking GLP-1 medications for diabetes and obesity are reporting additional side effects online that may not be fully captured in clinical trials

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When combined with a healthy diet and regular exercise, the results can be truly transformative

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They come from different populations, different treatment durations, different placebo runs, and different statistical estimands (for example, the efficacy estimand that assumes continued treatment versus the treatment-regimen estimand that counts discontinuations)

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