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Unlike older therapies that target a single pathway, tirzepatide works through two complementary hormonal systems involved in metabolism and appetite
In the brain, semaglutide reduces appetite, helping with long-term weight loss
Zepbound's evidence comes from SURMOUNT-1, also published in NEJM (Jastreboff et al., 2022)
Similarly, Wegovy (semaglutide) is FDA-approved to reduce the risk of cardiovascular death, heart attack, and stroke in adults with cardiovascular disease and obesity or being overweight
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