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Because it promotes new blood vessel growth, there is a theoretical concern in patients with active malignancy the same concern applies to any pro-angiogenic compound

MicroRNA 146a is believed to interact with intracellular mediators such as interleukin 1 receptor-associated kinase 1 and mammal-affiliated tumor necrosis factor receptor-associated factor 6, both of which are involved in cytokine-related signal transduction