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doi: 10.1016/j.ghir.2018.01.004 24 ZadikZLiebermanEAltmanYChenMLimoniYLandauH

For MC1R polymorphism studies, wild-type MC1R expressing cells as positive controls alongside variant-expressing cells are essential for quantifying functional impairment

It works by mimicking an incretin hormone that enhances insulin release, suppresses glucagon secretion, and slows gastric emptying, which in turn lowers blood sugar levels, as well as promotes weight loss

A BMI of 27 for men and women corresponded to being 20% above desirable weight and was associated with increased risks for hypertension (high blood pressure), hypercholesterolemia (high cholesterol), and diabetes mellitus, as well as premature death