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The aim of the trial was to evaluate the therapeutic effects of semaglutide 2.4 mg in patients with a suboptimal clinical weight loss response or weight regain, which was defined as less than 20% weight loss from their DOS, in line with an internationally endorsed definition of a suboptimal treatment outcome after MBS and previous published work in this area 39
By promoting satiety and reducing appetite, it helps patients achieve sustainable weight loss
However, excluding the outlier study [27] revealed a significant increase in WR in the GLP-1RAs treatment group compared to placebo (SMD = 0.49, 95% CI 0.12 to 0.86) (Supplementary Fig
GLP-1 primarily reduces appetite and slows gastric emptying, GIP enhances fat metabolism and insulin sensitivity, and glucagon increases energy expenditure and fat oxidation
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