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JAMA, 288(3), 321-333
More specifically, the researchers posited that the peptide participates in the mechanisms of transcription common for the epiphysis and retina
Given that efficacy is related to trough levels, more frequent dosing may be sensible in patients with augmented renal clearance (e.g., 1 gram IV q8hrs rather than 1.5 grams q12hrs)
Existing 1 H-MRS studies are small and show some conflicting results, with different studies focusing on different regions of the brain
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