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Specifically, ROS regulate various epigenetic marks, including DNA methylation, histone modification, and chromatin remodeling

Alpha-lipoic acid (ALA) is generally considered safe for most adults when it's used at standard doses of 300-600mg per day

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Excessive cytoplasmic lipid accumulation in cardiomyocytes leads to cellular lipotoxicity and thereby promotes a series of harmful conditions, such as insulin resistance and oxidative stress (Li et al., 2020)