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The newly approved medication is intended for people with MASH with moderate to advanced fibrosis - when patients are said to be on the cusp of cirrhosis
Major water-soluble derivatives of -glutamyl-L-cysteine peptides The figure shows the major water-soluble derivatives of -glutamyl-L-cysteine peptides: S-allyl-L-cysteine (SAC), trans -S-1-propenyl-L-cysteine, S-methyl-L-cysteine, and S-allylmercaptocysteine (SAMC)
This is important because GLP-1 drugs were originally designed to have a long half-life in blood to maximise their efficacy in the treatment of diabetes which prevents them from entering the brain (Hlscher)
10.1016/j.drudis.2020.06.026 34 SegataN.IzardJ.WaldronL.GeversD.MiropolskyL.GarrettW
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