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When healthy cells generate energy (adenosine triphosphate, or ATP) through the mitochondrial electron transport chain, they naturally produce highly reactive oxygen species (ROS) as a metabolic byproduct

Disclaimer: Long-term effects may vary

The skins transformation, the collagen remodelling, the improvement in elastin architecture, the regeneration at a cellular level, happens over weeks and months, and it is happening constantly, including on the days between your clinic visits

For bone surface erosion, we could see that SP@M could considerably inhibit bone erosion in the ankle and toe joints of CIA mice, which is even better than that in the MTX group