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In Phase 2 trials, retatrutide was administered as a once-weekly subcutaneous injection using a gradual dose escalation schedule to minimise gastrointestinal side effects
The research team transitioned 30 patients who had reached a weight loss plateau while on once-weekly semaglutide or tirzepatide to a reduced frequency schedule while maintaining the same dose
"Weight regain after stopping treatment may affect the long-term sustainability of the observed benefits
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