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Real-world data underscore this: nearly 65% of patients using GLP-1s for weight loss (without diabetes) discontinue within one year, as do about 47% of those with diabetes

Recent work has also shown that inflammation is closely associated with the elevation of BP, and that the inhibition of DPP-4 can reduce BP by regulating the function of the immune system, by reducing inflammatory reactions and by improving oxidative stress

Difficulty Breathing or Chest Tightness Serious side effects like difficulty breathing or chest tightness are rare but require immediate medical attention

Retatrutide and newer triple agonists Newer medications like retatrutide , a triple GLP-1/GIP/glucagon receptor agonist, will likely carry similar thyroid warnings based on the same rodent C-cell tumor class effect