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When Medication Adjustments May Help If reactions persist despite good technique, your clinician may recommend: Switching to a different formulation Changing injection frequency Exploring alternative formulations or supportive therapies Over-the-Counter Options That May Help If the steps above dont fully relieve symptoms, a few short-term, over-the-counter options can help calm mild injection site reactions: Hydrocortisone 1% cream applied once or twice daily for up to 3 days to reduce redness and inflammation Non-drowsy allergy medications such as loratadine (Claritin) or cetirizine (Zyrtec) to help with itching Cold compresses applied for 1015 minutes to reduce swelling and soothe irritation Fragrance-free moisturizer to support the skin barrier if dryness is contributing to irritation Topical anti-itch creams containing pramoxine or menthol for temporary itch relief A Reassuring Perspective Injection site reactions can feel frustrating, especially when everything else is going well

These include redness, itching, pain, swelling, and rash

De Filippis D, Esposito G, Cirillo C, et al

Archives of General Psychiatry, 65(12), 1447-1455