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Considering the temporal nature of hypovolemia following increased semaglutide dosage, improvement of the ischemic colitis on the second colonoscopy following drug discontinuation, and lack of signs of infection during the initial admission, semaglutide was still deemed the most likely culprit of the colonic ischemia

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LEADER Trial Investigators

FA subsequently activates the NF-B signaling pathway, promoting lymph node metastasis, which can be regulated by miR-144-3p under hypoxic conditions [229]