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By including all English-language studies on muscle mass loss during GLP-1RA therapy in T2D and obesity from major scientific databases and clinical trial registries, this narrative review synthesizes the current knowledge on the epidemiology and mechanisms of muscle loss in diabetes and obesity, with a focus on the impact of GLP-1RAs therapy

May reduce the impact of uncontrolled diabetes Long-term high blood sugar is associated with reduced amounts of glutathione

Patients may experience more pronounced gastrointestinal symptoms during titration, which can influence their willingness to continue treatment

This is one of the most common RAF undercoding scenarios in ambulatory risk adjustment