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10.3390/molecules24112062 Molecules
doi:10.1016/j.biortech.2012.10.168 Wang C, Zhang J, Wu H, Li Z, Ye Q (2015) Heterologous gshF gene expression in various vector systems in Escherichia coli for enhanced glutathione production
The glutathione administered is measured and fed into the bloodstream carefully for the best results
Measuring a second messenger (e.g., cAMP or Ca 2+ ) supports pathway engagement, but proving that the pathway is causally responsible for the cellular response requires additional evidence such as receptor antagonists, pathway inhibitors, receptor knockdown or knockout, or orthogonal rescue experiments
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