If you are pregnant, planning pregnancy, or nursing, avoid use until more data becomes available
Specific warning signs that require prompt medical assessment include: Symptoms suggesting nocturnal hypoglycaemia (night sweats, palpitations, confusion upon waking) Signs of pancreatitis (severe, persistent abdominal pain that may radiate to the back, accompanied by vomiting) [16] [1] Other severe gastrointestinal complications (persistent vomiting, signs of dehydration) Mental health concerns such as significant anxiety, depression, or mood changes Patients with pre-existing sleep disorders, such as sleep apnoea or insomnia, should inform their healthcare provider before starting Wegovy, as weight loss may improve these conditions but the medication could theoretically interact with existing sleep problems
Reduced-Frequency Maintenance (Wu, Cengiz & Lawley, 2025) Obesity examined patients taking semaglutide or tirzepatide every 24 weeks instead of weekly
PLoS One, 2014