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Key safety concerns identified in Phase 2 data include elevated resting heart rate, gastrointestinal side effects, increased hypoglycaemia risk when combined with insulin or sulfonylureas, and class-relevant cautions around pancreatitis and thyroid C-cell tumours

At visit 1 (randomization), the enrolled patients will undergo physical examination including antropometric measurements (weight, height and waist circumference) and blood pressure measurement, together with blood samples for standard endocrine and biochemical measurements

27 Pharmacological intervention can significantly reduce pain intensity and flare duration, e.g

For the establishment of subcutaneous xenograft models, MNNG/HOS cells (1 10 7 ) suspended in 150 L cold PBS were subcutaneously injected into the right flank of 56 weeks nude mice