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Alzheimers Dement 21:e70448
Severe Digestive Complications Despite being newer, tirzepatide drugs are already associated with: Gastroparesis (stomach paralysis) Ileus (intestinal blockage) Severe persistent vomiting Gastric outlet obstruction Cyclic vomiting syndrome The mechanism is similar to semaglutide: excessive slowing of gastric emptying
Its table rates overall stack efficacy versus tirzepatide alone as insufficient evidence, calling the synergy theoretical and not clinically validated, with no head-to-head randomized trial data published to date
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