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Excessive activation could theoretically lower seizure thresholds, promote excitotoxicity, or disrupt the balance between excitatory and inhibitory neurotransmission

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Metabolic reprogramming driven by oncogenes allows cancer cells to maintain deregulated cell proliferation, withstand metabolic challenges that are associated with diminished oxygen and nutrients, maintain a dedifferentiated state through alterations in global patterns of gene expression, and corrupt the surrounding microenvironment to actively facilitate tumor growth and dissemination 16,17,18