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To improve immunogenicity and potential strain coverage of rMenB, an outer membrane vesicle component obtained from the epidemic New Zealand strain was added to the formulation to create a four component vaccine, called 4CMenB ( From WGS Vaccine Antigen Discovery to a Licensed Vaccine Each component of the MenB vaccine had to satisfy a plethora of demanding regulatory conditions with respect to safety and immunogenicity, each having complex cost implications with respect to their manufacture and formulation
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