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GIP receptor activation in the brain may contribute to appetite regulation through mechanisms distinct from GLP-1 signaling, potentially explaining tirzepatide's superior weight loss compared to GLP-1 monoagonists

[1] [2] This effect is particularly pronounced early in treatment, though it may diminish somewhat with continued use

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How Peptides May Help Anxiety and Depression Researchers believe certain peptides may support the nervous system's ability to regulate stress, though most of this evidence comes from small studies and animal models rather than large clinical trials