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95% CI [0.770.99]).17 GLP-1 RAs are reported to be neuroprotective because of the ability to cross the blood-brain barrier and actions on neuroinflammation pathways.47 Besides atherosclerosis, oxidative stress is considered to be responsible for stroke development.53 GLP-1 RAs reduce oxidative stress and reactive oxygen species production via p-AKT/endothelial nitric oxide synthase and nuclear factor- B p65 pathways.47 CVOTs are being conducted in order to expand the indication of GLP-1 RAs from ASCVD prevention in diabetes to a broader patient population

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Therapeutic Applications Treatments currently approved for commercial use include Liraglutide (Saxenda, Victoza), Semaglutide (Ozempic, Wegovy), and Exenatide (Byetta, Bydureon)