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Loss of p53 expression reinforced HGF/c-Met signaling, which promoted invasion and metastasis by upregulating Snail expression (Liu et al., 2016)
J Biol Chem 271 : 2965929665
Therefore, emphasis should be placed on combining energy-restriction with a high protein diet and physical activity, to provide the maximal anabolic stimulus, ensuring weight loss is not associated with loss of muscle mass, or, more importantly, muscle strength [67, 68]
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