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Oxidative stress, an imbalance between the production of reactive oxygen species (ROS) and a cells antioxidant defenses, is associated with human diseases as well as aging

NSAIDs with longer half-lives, such as piroxicam (Feldene), are associated with greater risk of gastrointestinal bleeding than those metabolized more quickly (Roth 2011)

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It begins with the coagulation cascade, which promotes the release of thrombomodulin from vascular cells