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M Kimura ( 2.5 Pharmacokinetics The results of human pharmacokinetic trials are also of great significance for understanding the action mechanism of SGD, verifying the active metabolites predicted by basic research, and carrying out future pharmacokinetic and safety studies
The main scales for determining disease severity are the Kings College Hospital criteria (KCC)59 and the Clichy-Villejuif criteria,60 among others.61 Currently, the majority of transplantation centers use the KCC (Table 7), which have 68-70% sensitivity and 82-92% specificity, as well as an 80% positive predictive value in paracetamol-related ALF and 70-90% for other etiologies.62 The prognostic score proposed by the Acute Liver Failure Study Group (ALFSG), the ALFSG index, includes HE grade, ALF etiology, vasopressor use, total bilirubin levels, and INR, and is a better predictor of TFS than the MELD or KCC scores.63 However, it must be pointed out that prospective validation of this model is still pending
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