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Surprisingly, however, we found that glutathione also conferred protection in anaerobic time-kill assays (Fig
Importantly, when we compared OxPhos signalling in the same way to patients who did not receive 5FU-based chemotherapy treatment in the same cohort ( n = 90), we observed no difference in survival (Extended Data Fig
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More recent studies have shown that regional depletion of glutamine from PDAC tumors stimulates macropinocytosis by activating EGFR/PAK signaling and supplying glutamine via degradation of extracellular proteins in lysosomes 121
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