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Non-Polar Molecules: Molecules with low polarity are more likely to cross the BBB because they can more easily dissolve in the lipid bilayer
To prevent the contribution of dilution effects, metabolite data were mean-centered and the intensities of the spectral peaks of each given sample were normalized to the sum of all metabolite concentrations
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Most patients store their pens in the refrigerator door or a dedicated medication compartment rather than the freezer, which can cause ice crystal formation and damage the solution
