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Nausea is one of the most frequently reported adverse effects of this medication class, occurring because GLP-1 agonists slow gastric emptyinga mechanism that improves glycaemic control but can cause gastrointestinal discomfort
265,266 Similarly, the newly identified lncRNA -cell function and apoptosis regulator (Faar) ameliorates obesity-associated -cell dysfunction and apoptosis by upregulating the islet-specific genes ( Ins2 , NeuroD1 , and Creb1 ) by sponging miR-138-5p
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Additionally, individuals with severe gastrointestinal disease or severe kidney impairment should consult their healthcare provider before starting semaglutide to ensure it is safe for their specific health conditions
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