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Rather than promoting growth directly, it aims to clear dysfunctional cellular components that impede normal tissue renewal processes
Early phase trials showed higher mean eligibility (44.8% Non-Asian US) compared to late phase trials (31.9% Non-Asian US), reflecting less restrictive criteria in earlier development stages
For a 10mg vial, adding 1mL of bacteriostatic water creates a 10mg/mL concentration that works well across the full dose escalation range from 2mg (20 units) to 8mg (80 units)
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