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You should avoid alcohol entirely if you: Have a history of pancreatitis or are experiencing symptoms such as severe abdominal pain radiating to the back, as heavy alcohol consumption is a known risk factor for pancreatitis (NICE CKS Pancreatitis) Have active liver disease or significantly impaired hepatic function, as alcohol can worsen liver damage Experience severe or persistent gastrointestinal side effects from Wegovy, including intractable nausea, vomiting, or diarrhoea Have type 2 diabetes and are at risk of hypoglycaemia, particularly if taking insulin or sulfonylureas alongside Wegovy, as alcohol can unpredictably affect blood glucose levels (NICE NG28) Are taking other medications that interact with alcohol, such as metronidazole, certain antidepressants, or sedatives Have a history of alcohol use disorder or are in recovery, as resuming alcohol consumption poses significant risks Are pregnant or breastfeeding (noting that Wegovy is contraindicated in pregnancy and should be discontinued at least two months before planned conception, per Wegovy SmPC) Additionally, if you develop severe abdominal pain, persistent vomiting, or signs of dehydration after consuming alcohol whilst on Wegovy, seek medical attention promptly

10.1101/cshperspect.a028035 Cold Spring Harb