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Within each group, participants were randomised (1:1) to one of two treatment sequences of alternating oral formulations (1G and 2G) of semaglutide as detailed below (Fig
Human genetics
Due to their weekly dosing schedule and greater mean weight loss seen in trials (15% for semaglutide and 21% for tirzepatide, compared to 8% with liraglutide), semaglutide and tirzepatide are more frequently prescribed than liraglutide for treatment of obesity [33,34,35]
The SUSTAIN-6 clinical trial has shown that semaglutide significantly improves glycemic control in patients with T2D (Sorli et al., 2017)
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