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Shifts in this balance can alter the redox environment, potentially affecting bacterial survival under antibiotic pressure
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The STEP clinical trials have demonstrated average weight reductions of 10-15% of body weight over 68 weeks when combined with lifestyle modifications
Given this dilemma, shifting focus to alternative weight loss therapies that do not rely on the leptin-melanocortin system - such as GLP-1 RAs, which have distinctly different mechanisms of action - may offer theoretical feasibility for the treatment of MC4R -deficient obesity
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