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(2006) 291:E112430

One reason is being low in a type of compound produced within the stomach called intrinsic factor (a type of glycoprotein), which combines with vitamin B12 once consumed in order to allow it to be absorbed

Potential risks of bias were assessed for all studies using tools specifically developed for this purpose, such as the RoB 2 (revised Cochrane risk-of-bias tool for randomized trials).11 This tool assesses bias on 5 different domains: bias from randomization, bias due to deviations from planned intervention, bias due to lack of outcome data, bias of outcome measurement, and selection bias of reported outcome

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